Albumin synthesis decreases as part of the acute response. Liver under acute responses starts to synthesize C reactive protein, IL-6 and other factors decreasing albumin synthesis.

regards,

But this doesn't explain its role.

So called "negative" acute-phase proteins, e.g. albumin and others, decrease during an inflammation to save amino acids and energy for the synthesis of the proteins mentioned above.

Under conditions of widespread, chronic inflammation (i.e. septic shock), it is also likely that a majority of albumins have left the plasma compartment and extravasated into the tissue, meaning they would be undetectable in a plasma sample. This is secondary to increases in vascular permeability which are characteristic of this disease.

Albumin is a protein essential in our organism. Transport a lot of subtenancies and is produced by the liver. In the inflammation response, the organism stop albumin production as soon as the liver can, because transport is not necessary. Also less proteins are necessary and other are so necessary, so the organism is preparing to attack external elements or inter proteins detected by our body such as enemies. So at the end the truth is that you do not need albumin to transport anything, so forget to expend energy producing and livery albumin to the blood.

I hope I help you, and always remember the body do the body learn, so if I do not need to produce and spent energy in something I do not do it. Body is here from many years, when the live start, so you are the same genes than the first organism appear in the hearth. If you remember that, probably you understand why your body do that or not. Remember you only want to be alive for the future, you want to do reproduction and to leave here yours genes. So why expend energy in stupid things. If there are inflammation your body need energy to prepare to the next war. Someone want to eliminate me and probably I can not have a future of me. Live are so egoist.

Albumin is a plasma protein normally confined to the vasculature (blood vessels). Many inflammatory processes and mediators cause the blood vessels to become leaky, such as PGE2. The leaky vessels then allow the extravasation of large molecular weight proteins such as albumin into the tissues. This results in oedema formation and in a lowering of the albumin concentration in the plasma. Hence, as stated by others albumin is a 'negative' acute phase protein - reducing in concentration rather than increasing during inflammation. Dyes such as Evans blue bind to albumin and the extravasation of the albumin can be clearly demonstrated when Evans blue is given i.v. to an animal and a mediator such as PGE2 is injected intradermally. A blue area will develop in the injected skin over time and this can be quantified and correlated with the amount of PGE2 injected.