Hi Dewan,

Check this article. Hope this will answer your question

https://www.nature.com/nrn/journal/v10/n3/full/nrn2591.html

Hello Dewan,

atrogliosis is a process which occurs after SCI and leads to expression of numerous signaling molecules. Two scar types form after SCI , the glial scar and the fibrotic scar. The fibrotic scar in the lesion core is packed with growth inhibiting molecules like NG2. The glial scar area also contains molecules which inhibit axon growth like NOGO. Beside these growth inhibiting structures there are multiple factors influencing axonal growth cones like immune cells etc. I guess I didn‘t answer your question on the molecular pathways causing astrogliosis, but I felt like adding this bit of general information might be useful. Best regards, Nicole