I am interested in starting-up a project investigating propable new pathways of
- systemic inflammatory response syndrome (SIRS),
- compensatory anti-inflammatory response syndrome (CARS) and
- mixed anti-inflammatory response syndrome (MARS)
in course of acute pancreatits. Do you have any toughts, or suggestions on this topic?
They are all important topics and looking at all 3 in depth would be enough work for a lifetime. I would focus on one - have a look at your patient population to help you choose which one as they present in decreasing frequency so meaningful study may take years! - read some reviews on where we are up to and decide at what point you would like to contribute, taking into account sample availability, funding and local expertise. Good luck.
it looks like that CARS do not exist - please read Hector Wong papers...
I will focus only ON SIRS, CARS is already an old concept clinically no pertinent as MARS.
In the last 90 ‘, our group have studied the relation between SIRS/ severe acute pancreatitis (SAP)/ and pro and anti-inflammatory cytokines during SAP.
The related papers being published during 1999- 2001, are not more easily available on the Net, but they are in my contribution section of RG.
I send you in PDF:
Pancreatitis, Cytokines and SIRS: Déjà vu all over again? The CCM Editorial related to our prospective study:
Pro- and anti-inflammatory cytokines during acute severe pancreatitis… CCM , 1999 ,27, 749-755
The Letters to the Editor concerning this publication.
SIRS during Acute pancreatitis, the English abstract of my expert communication for the French Consensus Conference (2001), full text in French language which may translated…
And an abstract: Acute Pancreatitis during SIRS focusing on the incidence of pancreatitis (multicenter prospective ICU study) Intensive Care Medecine 1997
These publications could help you