can anyone simplify the action potential of cardiac muscle and is there any variation is present between canine and human action potential of cardiomyocytes?
Dear Yogeshpriya Somu: Most of heart cells including canine or human ones had a long duration of cardiac action potential with about 200-300 msec. The shape of action potentials between canine and human cardiomyocytes was quite similar with five phases (phase 0, 1, 2, 3 and 4).
Maybe it's worthwhile for you to read e.g. these three studies (and other papers from András Varró):
https://doi.org/10.1113/jphysiol.2013.261198/
https://doi.org/10.1007/s00424-013-1309-x/
https://doi.org/10.1113/10.1007/s00424-005-1445-z/
Hello, A medline/pubmed search will provide the above mentioned papers.
In addition, there definitely is a variation of cardiomyocyte action potentials across species. You may find much more quantitative information regarding dog cell and tissue measurements for obvious reasons. In the human, Varro, Yoram Rudy, A. K. Workman, Arie Verkerk, multiple Japanese groups associated with Akinori Noma, and others have made some detailed measurements from various tissue types.
Sorry, ResearchGate messed up the doi-links... Just remove the part (https://www.researchgate.net/deref/) that RG adds to the links.
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