My company Planet Biotechnologies Inc is interested in two areas of research with respect to the COVID-19 pandemic. Firstly, the role of mitochondrial dysfunction in innate and acquired immunity in COVID-19 infection and how clinical outcomes might be improved (both in terms of severity and duration of illness) by a nutraceutical cocktail made up of active ingredients that have been shown previously in the literature to have broad-spectrum antiviral activity and that satisfy GRASE regulations and thus could be brought to the clinic very rapidly. Secondly, we are interested in drugs already in clinical use that might be repurposed to exploit the high uracil content of the virus with a special interest in those that target DHODH. Side-effects of the drugs include immunosuppression that might be ameliorated by co-administration of dCytd, dUrd and/or dThyd.
The main structure of the cell used by SARS-CoV-2 used for replication is ribosome. However, mitochondria has certain role in vaccine development.
1. https://asm.org/COVID/COVID-19-Research-Registry/Basic-VIrology
2. https://www.preprints.org/manuscript/202004.0269/v1
3. https://www.mitoaction.org/covid-19-newest-prevention-method-dynamito-mitochondria/
Thanks for your reply Muhammad but we are not interested in developing a vaccine but rather a therapeutic regimen that might be brought to the clinic rapidly but also has proven safety and efficacy for other viruses before a vaccine is developed.
Hi
Please check the following link. I believe it will help you.
https://mitochondrialdiseasenews.com/information-about-covid-19-for-mitochondrial-disease-patients/
Regards
Very nice topic.. In my opinion improved mitochondria function of immune cells can indirectly help to managements of covid-19.
I am working on improving immune system during rehabilitation of covid-19 focusing on role of physical activity.
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