Direct compression.
Yes, of course!!!
May affect physiochemical properties
What do you say, for example, hydrophobic nature of drug?
Examples of physicochemical properties affecting blend uniformity include ( but are not limited to):
- particle size
- particle shape
- particle size distribution
- density
- cohesivity
- hydroscopicity
- hardness
- tendency to segregation of individual components ( based on shape and density).
Yes, they do change the blending property owing to their bulk property such as crystallinity, polymorphism etc.
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