What is the possible formulation approaches for reduction of the Hepato-toxic side effect of nimesulide?

More Ramy Elsergany's questions See All

In gene bank submission, what is the reason of "your seq. contains stop codons" ?

I am trying to submit sequences of COX-1 gene(mitochondrial gene) to gene bank. My sequences is almost 100% identical to a published one. It return a message saying that they contain stop codons...

12 April 2024 3,503 0 View

Question about article submitted and references does not appear ?

I submitted a book chapter, and the references did not appear, although I added the DOI of it, and the references were mentioned on the page of this chapter

24 March 2024 3,049 1 View

Why references in Arabic aren't cited in ResearchGate such as references in English?

why references in Arabic aren't cited in ResearchGate such as references in English?

01 September 2023 1,700 0 View

How do we increase the number of citations, although it was mentioned in several of articles in RG but not archived?

how do we increase the number of citations, although it was mentioned in several articles in RG but not archived?

26 August 2023 4,601 1 View

How to add publications policy to researches and book at researchgate?

how to add publications policy to research and book at researchgate?

24 August 2023 974 0 View

Why i see the citation of my research in the article but not counted in my score?

how to register my citation of my research in my Score?

18 August 2023 6,173 2 View

Is there any technical way to register citation in published articles and count it among my research score?

ways to register citation of my research in my research score

18 August 2023 2,406 1 View

Procedure for DNA gyrase ?

I want to work on DNA gyrase for mosquito which treated with insecticides.

24 October 2022 4,577 0 View

Standard(s) for evaluation the performance of thermal driven cyclic heat pump like adsorption cycle??

Dear All, I am looking for international standard(s) to evaluate the rated capacity of thermal driven cyclic heat pump such as adsorption cycle for cooling or heating purposes. Do you have...

17 December 2021 763 6 View

Is it possible to identify all possible Irreducible Infeasible Sets (IIS) for an infeasible Integer Linear Programming problem (ILP)?

For an Integer Linear Programming problem (ILP), an irreducible infeasible set (IIS) is an infeasible subset of constraints, variable bounds, and integer restrictions that becomes feasible if any...

03 November 2021 3,307 2 View

What are the long-term impacts of incarceration on youths' developing brain?

I want to explore the long-term effects of incarceration on a youth's developing brain. I also want to explore research that looks critically at incarceration and punitive measures as the primary...

12 August 2024 862 0 View

For an in-vitro drug release study, what molecular weight cut-off (MWCO) dialysis bag is required for a 117 kDa protein?

kindly reply me. Thanking you in advance.

05 August 2024 7,727 4 View

What should Berlin do as a city to become as impactful as London and Paris in World Football?

Please go through my Abstract. I can also share a proposed Thesis Outline.

04 August 2024 2,077 0 View

Some new emerging problems on application of RL for scheduling in IoT networks?

I have seen plenty of existing works on applied Reinforcement Learning (RL) policies for optimized scheduling in IoT networks including Q-learning, DQNs, and the newer ones including PPO for...

01 August 2024 8,754 2 View

Why 3 replicates for most biological assays? Is it enough to examine the data fits normal distribution?

Just bounced on me. Before statistically analysing significant difference, shouldn't we see if data fits normal distribution first? Is 3 replicates enough to testify the hypothesis of normal...

31 July 2024 8,141 13 View

What are the roles of innovation in achieving the Sustainable Development Goals (SDG)?

31 July 2024 3,533 2 View

How to find projects for a team of professional developers in AI?

We are looking for projects for a team of professional developers About us We are a team of experienced developers with over 10 years of experience in various programming fields. Our mission is to...

30 July 2024 8,377 0 View

Inquiry on Maximum Nucleic Acid Volume for 2.5 mL Liposome Solution?

I am currently working on a project involving liposomes and need to determine the maximum volume of siRNA that can be added to a 2.5 mL liposome solution with a total lipid concentration of 10...

30 July 2024 6,420 1 View

Hi there, someone has the SeinFit software for windows because I cannot download it?

DOS version.

29 July 2024 6,064 1 View

There is possible way to calculate experimental DOS from the UPS spectrum of the material. How to calculate the DOS from UPS?

Here, I have attached the UPS graph. I'm trying to calculate the DOS/DOVS from the UPS.

29 July 2024 4,971 1 View

Ramy Elsergany

Nimesulide has a known a pre-gastric absorption, so Zydis technology in which the drug can be formulated as an orally lyophilized tablet for intra-oral administration can be a successful idea for bypassing liver metabolism. AUC of nimesulide by Zydis technology is 62% higher when compared with conventional tablets. So, the dose of nimesulide can be reduced to obtain the same Cmax obtained with conventional tablets which consequently leads to side effect reduction.

Hassan Reza

Why not if we go for Oro dispersible tablets(odt)???