MS is mainly a chronic, inflammatory demyelinating disease.

If neurodegeneration is secondary to inflammation or these two processes occur in parallel way is still detabed.

Multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) are different diseases with some similar features and symptoms.

They both:

·         Affect muscles and your ability to move your body

·         Attack  brain and spinal cord

·         Have “sclerosis” in their name

·         Cause scarring or hardening around nerve cells

They have some key differences, though. MS is an autoimmune disease that causes your body to attack itself. ALS, also called Lou Gehrig’s disease, is a nervous system disorder that wears away nerve cells in your brain and spinal cord. Both are treated differently.

People with MS often experience greater mental impairment than people with ALS. People with ALS typically develop greater physical difficulties

Thanks a lot Luca and Shamim. Much appreciated..

Wrong question: MS is not a neurodegenerative Disease. A meaningful question could be: what have MS and neurodegenerative diseases in common?

Thanks  a lot. Actually on the basis of these links I have posed this question. Yet now I dont know clearly about it. 

https://www.youtube.com/watch?v=gF4s9wqhn-0

http://www.ncbi.nlm.nih.gov/pubmed/23755367

Multiple sclerosis is a disease of Central nervous system with demylination occuring at Multiple occasions followed by often incomplete recovery, followed by secondary axonal changes which may be called degeneration in a way. Here, worsening occurs with each relapse of MS rather than a progressive degeneration. In neurodegenerative diseases - there are plenty of them- like Parkinson's disease, motor neuron disorder(ALS) there is no demyelination, however there is downhill course of disease generally. 

Tests that measure the sense of smell may soon become common in neurologists' offices. Scientists have been finding increasing evidence that the sense of smell declines sharply in the early stages of Alzheimer's, and now a new study from the Perelman School of Medicine at the University of Pennsylvania published today in the Journal of Alzheimer's Disease confirms that administering a simple "sniff test" can enhance the accuracy of diagnosing this dreaded disease.

The sniff test also appears to be useful for diagnosing a pre-dementia condition called mild cognitive impairment (MCI), which often progresses to Alzheimer's dementia within a few years.

Neurologists have been eager to find new ways to identify people who are at high risk of Alzheimer's dementia but do not yet show any symptoms. There is a widespread consensus that Alzheimer's medications now under development may not work after dementia has set in.

"There's the exciting possibility here that a decline in the sense of smell can be used to identify people at risk years before they develop dementia," said principal investigator David R. Roalf, PhD, an assistant professor in the department of Psychiatry at Penn.

Roalf and his colleagues used a simple, commercially available test known as the Sniffin' Sticks Odor Identification Test, in which subjects must try to identify 16 different odors. They administered the sniff test, and a standard cognitive test (the Montreal Cognitive Assessment), to 728 elderly people.

The subjects had already been evaluated by doctors at Penn with an array of neurological methods, and according to expert consensus had been placed in one of three categories: "healthy older adult," "mild cognitive impairment," or "Alzheimer's dementia." Roalf and his team used the results from the cognitive test alone, or combined with the sniff test, to see how well they identified subjects in each category.

@ Marianne Levon Shahsuvaryan: i don't think that this has anything to do with MS.

Neurodegeneration and neuroinflammation show nothing that would set them specifically apart.

It is only in focusing on specific structural findings and truly unique features of their development that any cases of MS, ALS, Alzheimer, Parkinson - any disease "defined" in adducing unexplained neurological or mental findings - will ever be indubitably identified ... and cured.

Really, Ghulam Md Ashraf? And actually not in the ways in which Dawson's fingers center on veins, and thereby spread in space and in time?

Congratulations to anybody who first rises any concrete objection to my review of the subject matter!

Agreed, Dr. Ashraf. Indubitably differentiating a symptom-defined condition, be it MS, AD, or PD, appearing characterized by some "primary" instead of specific myelin, protein, other tissue property is harder than tough. Consider it wise?

Indeed, Dr. Ashraf. But who is aware of Jean-Martin Charcot's introduction of 3 to 4 non-specific symptoms (instead of his specific autopsy findings) for introducing MS? Of his having similarly introduced ALS?