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Questions related from Grandhi Venkata Ramalingayya
Dear Researchers, We are working on hippocampal slice electrophysiological studies for assessing spike potentiating effects of cholinergic agonists like carbachol. For the evaluation of M1PAM...
23 October 2017 1,120 2 View
Dear Researchers, We are working on hippocampal slice electrophysiology using MEAs' from multichannel systems, Germany. We are testing spike potentiating agents, like carbachol in CA1 region of...
16 March 2017 1,289 0 View
Dear Researchers, We are working on acute hippocampal slice preparations for electrophysiological studies using MEAs' (P28 Wistar rats). We are getting good viable slices with spontaneous and...
08 March 2017 2,460 5 View
Dear Researchers, I am working on hippocampal slice electrophysiology using micro electrode arrays (MEAs'). Although there were evoked signals (at 2-3 V stimulation) without any doubt in slice...
01 March 2017 8,371 4 View
Dear Researchers, If anybody worked and come across with clinical or preclinical effective therapy with AChE inhibitors especially in menopause condition, please suggest us your ideas and inputs...
20 February 2017 1,099 8 View
Dear Researchers, We are working on post-menopause related dementia and AD. We have noticed that, in post-menopuase women no therapeutic intervention is approved for memory impairment except the...
20 February 2017 2,638 2 View
Dear Researchers, We are working on acute hippocampal slice electrphysiology using MEA's. We are able to get the spontaneous activity in slices made from vibrotome using isoflurane anaesthesia to...
03 January 2017 2,318 7 View
In preparing the ACSF solution, is it a mandatory and crucial to evaluate the osmolarity of ACSF solution? Also whether it will have influence on hippocampal slice viability? Further, what would...
07 December 2016 3,153 5 View
We are working on post menopause associated dementia animal models using female ovariectomized rats. Literature says that surgical menopause can be induced in female rats immediately, but we wish...
05 November 2016 5,388 1 View
Literature says the conventional acetylcholinesterase inhibitors (e.g. Donepezil) or HRT is not that effective in treating the post menopause associated dementia in women.However, the aged women...
26 October 2016 319 8 View
We could not find EPSP's or population spikes with the protocol mentioned 3 V stimulus using MEAs from multichannel systems. Anybody who has experience with MEAs, please suggest us in this regard....
19 October 2016 5,359 19 View
We are working on Acute hippocampal slices for electrophysiological recordings using MEAs (Multichannel Systems) in rats. We could not find any evoked or spontaneous firing of slices (350-400...
10 October 2016 2,955 7 View
