What is the effective treatment intervention for Post Menopause Associated Dementia in elder women other than HRT or AChE inihibitors?

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Olakunle J Onaolapo

Anxiolytics and antidepressants can also be of help.

Judit Málly

I have very bad experiment with AcHE inhibitors. Patients became excitated, without any mental improvement.

The best is the non-invasive brain stimulation and 30 minutes relatively fast walk every day.

The transcranial directcurrent stimulation is relatively cheap and patients can use it at home.

Best regards,

Grandhi Venkata Ramalingayya

Thank you for the suggestions given...

Best Regards,

Dr. Grandhi V Ramalingayya

Prof. Dr. Shahid H. Sheikh

Grass root pathology of Dementia, Alzheimer and Parkinson's is the Neuronal Sub-Nucleus, induced by the CMV & HSV RNA proliferation.

Best thing to do is to run the viral serology test and measure the antibodies against these viruses. Then, with the given load design the antiviral therapy to alleviate the Neuronal burden. Also the test of CD4/CD8 must be taken in to account to enhance immunity exogenously.

Alba Sierra-Marcos

Regarding non-pharmacological interventions, 'Computerized Cognitive Training' has demonstrated its effectiveness in cognitively healthy older adults (Computerized Cognitive Training in Cognitively Healthy Older Adults: A Systematic Review and Meta-Analysis of Effect Modifiers, Lampit et al. PLOS medicine 2014).

We believe that this effect may also be present in mild dementia, regardless of the underlying etiology.

Best regards

Dear Alba Sierra-Marcos,

Thank you for the information provided...

Please let me know whether the finding you have mentioned is in especially post menopause associated dementia patients?

Thanking you,

Grandhi V Ramalingayya

Christophe Tzourio

Dear Grandhi,

the bold answer is that there is no treatment for dementia whatever the category of patients. Ache inhibitors have some short-term effect in patients with Lewy body disease but fail to show any efficacy otherwise. Other therapeutic strategies like cognitive training have not shocn yet convincing proofs of efficacy. We have so far only small measures like lowering vascular profile (hypertension, diabetes) in order to reduce the vascular part of dementia and suggesting to patients to do regular physical exercise and maintain social activities.

best

Christophe

Thank you for the valuable suggestion given...