Article Remineralisation properties of innovative light-curable resi...
The Conclusion states:
One of the main principles in minimally invasive dentistry is
based on the execution of therapeutic restorations that may
combat the carious process and remineralise the dental hard
tissues. >> Zn added as the bioactive micro-llers tested in this study represents apossible and valuable choice to remineralise dental hard tissues..... when used (as adhesive systems?) , cavity layers or temporary therapeutic materials....
Further in the excellent Article we can read :
"..... the durability of resin–dentine interface represents one of the main concerns in adhesive dentistry as it is affected by severe degradation.
This occurs mainly via water sorption and hydrolysis of monomer methacrylates ester bonds caused by salivary esterases.
The hydrolysis of collagen fibrils at the resin–dentine interface
is enhanced by activation of MMPs.
Nevertheless, the incorporation of more hydrolytically stable
resin monomers and/or the use of matrix metalloproteinase
inhibitors may not be able to address the replacement of the
mineral phase within the demineralised dentine collagen.
The use of bioactive materials which promptly interact with dental
hard tissues through therapeutic/protective effects might
provide a feasible means to extend the longevity of .....> WHAT >>???.....( resin–dentine bonds?? ) >
> IMO it's TIME to RECONSIDER the GOAL as follow :.... to extend the longevity of ... caries-affected residual tooth stucture &vitality, via remineralisation of the dentine collagen and fossilisation of MMPs !
All comments are welcome
Thanks
The beneficial effects of Zn in remineralizing dentin is well documented in the literature. I have my contributions on the subject is available there.
Nikhi Sarkar [aka, N.K. Sarkar]
The element Zinc has long been [not just 6 years] known a strong remineralzer ofdentin.
Nikhil Sarkar
Dear Nikhil Sarkar ,
thanks for your reply, indeed the effects of Zn in remineralizing dentin are well documented, ( can you please give the link to your contribution ? )
Further the question was about to know if, 6 years after the Article ( mentionned) there has been some significant progresses on the use of Zn-ions, as additive component in developping new restorative materials...... which was suggested, from the Authors of the same article, as a promising way !
Unfortunately it seems that there has been little advances on this field, moreover the recent attention given to Zn-NP's may further cause delay in delivering substantial results...?!
Regards
Nicola
You should contact Dr. Toledano and Osorio (University of Granada, Spain) to get more evidence about that. They have been working on that type of topic for more than 10 years. They also have several clinical trials and a patent on that.
Dear Salvatore Sauro , I do follow their findings but I have the impression that there is recently not so much progresses or a decreased activity on Zn- topic.
Thanks anyway
Nicola
Zinc is an element closely linked to the biodegradation of dentin, related to matrix metalloproteinases. All materials in dentistry that have zinc content have an effect of "arrest" of caries and intervene favorably in the remineralization of dentin.
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