Online surveys for social sciences researchs: what are your opinions about this tool and how can we improve the research design to incorporate online?

Good morning everyone, Due to the pandemic, I conducted several online surveys. It is quite agile, not at all expensive, but there are several problems: the sample's representativeness and its...

21 February 2021 7,457 3 View

Does early COVID 19 treatment matter ?

The SARS-CoV-2 virus spreading across the world has led to surges of COVID-19 illness, hospitalizations, and death. The complex and multifaceted pathophysiology of life-threatening COVID-19...

29 December 2020 7,446 4 View

Is there a paper summarising optimisation techniques and their properties such as convergence speeds ?

I am looking for a document that summarises mathematical results for optimisation techniques : steepest descent, newton and quasi-Newton, their convergence speed in different settings...

19 December 2020 2,908 8 View

What part of heart ?

Hello You can see a transversal slice of a mouse heart in microscopie with blue coloration. My question : what part of the heart is it ? how i can recognize difference between histology of...

01 December 2020 1,000 3 View

Does solar activity have an higher effect on climate change than CO2?

I started a research on analyzing some 23 indicators which are all somewhat related to influence climate change. The objective of my research is relating all indicators together by considering the...

30 October 2020 8,783 51 View

How to estimate magnetic permeability of composite materials (Fe and paramagnetic materials)?

Do works exist about magnetic permeability calculation of ferromagnetic composite materials such as SMC or mixe of iron powder and epoxy at lower density of iron than SMC?

14 September 2020 5,591 1 View

Is there an R package for the equivalent of a Mixed ANOVA in permutation ?

Hello, I know there is an R package for permutations with two independent samples...

06 August 2020 495 2 View

Hi. I am doing a western blotting investigation, and found in different cell lines bands with different weights... Why this hapenned?

I am using anti-fibronectin antibodies in western blotting experiments, and in one breast cancer cell line, I found ~230kDa bands, but in other cell line of this cancer, I found bands of ~35kDa...

02 July 2020 10,015 3 View

What are the current best options to deplete rRNA in Arabidopsis?

I am interested in mRNAs only (also the ones from chloroplast). RNA input x RNA yielded approximately? Additional Kit used to concentrate RNAs + to get rid of other RNAs (tRNAs, etc...)? Thank...

01 June 2020 1,002 1 View

What analytical method is the most adapted to the determination of Rare Earth Elememt-bearing minerals in rock and lateritic soil samples?

I am planning to work on the mineralogy of the rock and lateritic soil samples of the Bingo carbonatite complex in order to determine its REE-bearing minerals and determine its REE prospectivity....

17 May 2020 1,219 18 View

Is there anyone who experienced with cytotoxic effect of Hoescht 33342 dye?

Is Hoechst toxic to cells? In general, it is known as non-toxic. I am working with dsRED MDA-MB-231 cell line. I applied it for my PDMS-based microfluidic platform, for this reason, I incubated...

26 February 2021 9,119 3 View

Does anyone have any ideas why drug-resistant malaria is increasing in Southeast Asia even when those drugs are no longer used?

When dealing with bacterial toxins, there are three varieties of microbes that develop in your petri dish: toxic, resistant, and susceptible. Initially, there are only toxic and vulnerable...

21 February 2021 6,084 5 View

How to dilute Toxin-DMSO solution?

I have a concentrated solution of a toxin(50 micromolar) in DMSO 100%. I need to dilute it inorder to dilute both the toxin and DMSO wich can be toxic to cells. Which would you guys recommend to...

19 February 2021 7,447 2 View

Has anybody administered MK-2206 (an orally active, allosteric inhibitor of AKT) intravenously to the mice?

We aim to use MK-2206 to inhibit AKT in mice. However, a large body of studies suggests that it should be administered orally. I was wondering if somebody could tell me that is it toxic for the...

07 February 2021 6,340 1 View

Why do high doses of humic substances inhibit the growth of corn roots? Is there a toxicity effect?

Length, volume, surface area and dry mass of corn roots treated with humic substances increased up to 13 liters per hectare and decreased with higher doses.

02 February 2021 2,190 4 View

How to create a graphic with two curve ??

Hello, i want to do a graphic with two curve to compare a toxicity of two metals in spss but i don't know how to do this. Can anyone help

01 February 2021 9,371 7 View

Which are the appropriate solvents for n-hexane plant extract for in vivo animal models to avoid toxicity?n-hexane plant extract is not soluble?

My n hexane plant extract is not soluble in any solvent. I have tried water, normal saline, tween 20 (2%, 5%, 10%, 50%), tween 80 (2%, 5%, 10%, 50%), pure DMSO, ethanol (2%, 5%, 10%, 50%, 97%),...

16 January 2021 3,547 3 View

What is the most appropriate design (statistic test) to assess the toxicity of 2 different compounds at 6 different concentrations and 2 conditions?

10 January 2021 8,077 3 View

Does the initial cell number play a role in affecting the output variables like IC50, EC50, etc.in cell-based drug screening assays? If so, how?

While performing cell-based assays to assess drug toxicity or drug efficacy, how is the initial cell seeding density determined? What is the standard followed in the pharmaceutical industry while...

07 January 2021 6,983 3 View

What is the most suitable program for determine the state of synergesm, antagonism or addition of mixing two or more toxicants?

In a toxicology experiment the mixing pattern of two or more toxicants required for the physiological or lethal effect. what is the suitable program or equation that I can use?

06 January 2021 7,419 3 View