I will appreciate if you could share your working experience with conventional/patient-derived xenograft models of acute myelogenous/lymphoblastic leukemia ? How its different from solid tumor xenografts in terms of tumor growth and other characteristics?
You may inject the leukemia cells into vein of immun-dificient mice and about 30% will grow leukemia. You may then analyze what ever you can get.
We've done xenografts commercially with AML cell lines like MOLM-13 (http://altogenlabs.com/xenograft-models/leukemia-xenograft-model/molm13-xenograft-model/) and MV4-11 (http://altogenlabs.com/xenograft-models/leukemia-xenograft-model/mv4-11-xenograft-model/). In order to get statistical results from growth curves, we place the cells in matrigel so it turns into a solid tumor in the mice. Non-solid tumor xenografts are difficult to deal with as finding the "tumor growth" is not a trivial process.
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