Mat lab is a best source for calculating the efficiency of an electric vehicle by simulate mathematical model. In that you have to develop an mathematical model for your vehicle from that you can able to calculate efficiency reliably....
As the previous answer, I confirm that Matlab/Simulink is a good option with its vehicle toolbox. Indeed, we have already use it in different EV contexts as shown with the attached papers.
If you want to develop physical models from scratch, Bond Graph (BG) is a very good option. Many simulation packages like 20-SIM, SYMBOLS Shakti, Modelica etc can be used to simulate the BG Model. However learning BG can take some time.
You need to consider the components separately and assembled together. Manufacturers of components are the best source of information about capacity and efficiency. Components are the electric motor, the auxiliary motor if there is one, the battery capacity and weight, the charging system at home base, and recharge underway, plus heating and light..
Typical over all efficiencies are usually around 50%, with 25% being a poor limitation on the project. When components are limited by cost to around 95% each, a 4 component system gets the ideal efficiency of about 80%. All of these numbers can be improved both in cost and technical performance, with additional research and development.
In simulation you need to supply the actual performance of individual components.