Actually I have found in some papers that Octanol is used in some product purification from bacteria, but I dont know what is the principle behind this procedure?
No correlation has been found between the hydrophobicity of the substituent on the alkyl backbone of the solvent and the location of the transition point in toxicity. The logP(octanol), above which all solvents are nontoxic, is used to express the solvent tolerance of the bacteria. Article Toxicity of homologous series of organic-solvents for the Gr...
Dear Rajesh, 1-octanol is an alcohol immiscible in water, its solubility at 25 ° C is just 4.1 mmol / L; it is possible that in culture media this solubility is lower. However, at concentrations below saturation it has prominent antimicrobial effects. In the case of Acinetobacter calcoaceticus, a 50% inhibition of growth is achieved at a concentration in the culture medium of 0.80 mmol/L. This bacterium offers an adaptive response similar to that found in E. coli and P. putida which consists of a change in the composition of cell membrane lipids, specifically a change in the degree of saturation of fatty acids. More details can be found in the article of Kabelitz et al. (2003, and internal references) that I attach.
The antimicrobial action of a solvent correlates
with its hydrophobicity as expressed by the logarithm of the
partition coefficient of the compound in a mixture of noctanol
and water (log Pow). Organic solvents with log Pow
values between 1 and 5, such as toluene, are highly toxic for
microorganisms. This influence of hydrophobicity on toxicity
can be found in different solvent classes, e.g., aromats,
alcohols, phenols, and alkanes (Laane et al. 1987; Rezessy-
Szabo et al. 1987; Sierra-Alvarez and Lettinga 1991;
Osborne et al. 1990; Sikkema et al. 1994).
- Badges
- Science topic
- Similar topics
- Papers