I'm planning on acid-extracting histones from bone samples by dissolving the bone with EDTA, and then precipitating the CaEDTA with 2 molar equivalents of HCl (determined experimentally to be the correct ratio), followed by adding additional HCl to a final pH=0.40 (corresponding with an acid extraction with 0.4M HCl). 

I would idealy like to precipitate the acid extracted histones with TCA, and follow it up with cold acetone washes.  However, I'm worried that this might damage the DNA bound to the histones.  Any suggestions on this would be most welcome!