Hi, there is increase in lobes of the neutrophils as they mature to ensure nuclear flexibility as they move fast to point of infection .

Increased lobes confer increased nuclear flexibility, thereby easing the migration of neutrophils through narrow channels. The Increased lobes of the nucleus may also play a role in intranuclear chromatin organization and Gene expression.

Thanks, but Providing nuclear flexibility is i guess one of the advantages that Neuutophils are getting when they increase number of lobes,but how and why it is actually happening? Any molecular mechanism behind it? @emmanuel