Environmental and lifestyle changes resulting from industrialization and migration to urban environment from rural settings may be responsible to a large extent, for this epidemic of Type 2 diabetes. Obesity, especially central obesity and increased visceral fat due to physical inactivity, and consumption of a high-calorie/high-fat and high sugar diets are major contributing factors. There is also strong evidence that Indians have a greater degree of insulin resistance and a stronger genetic predisposition to diabetes. As several of the factors associated with diabetes are potentially modifiable, this epidemic of diabetes can be cured if proper measures are taken to increase physical activity and reduce obesity rates in adults, and most importantly, in children.

Environmental and lifestyle changes resulting from industrialization and migration to urban environment from rural settings may be responsible to a large extent, for this epidemic of Type 2 diabetes. Obesity, especially central obesity and increased visceral fat due to physical inactivity, and consumption of a high-calorie/high-fat and high sugar diets are major contributing factors. There is also strong evidence that Indians have a greater degree of insulin resistance and a stronger genetic predisposition to diabetes. As several of the factors associated with diabetes are potentially modifiable, this epidemic of diabetes can be cured if proper measures are taken to increase physical activity and reduce obesity rates in adults, and most importantly, in children.

Sarmistha, you are correct about modifiable risk factors. The issue is that the environment, supported by the food industries (manufacturing and sales) is obesogenic. Technology also contributes to sedentary activities that interfere with physical activity (outdoor play) in children and young adults. Fast food restaurants can offer low-cost meals to vulnerable populations. Unfortunately, these meals are high in sugar and unhealthy fats, while low in fiber and micronutrients. There needs to be a paradigm shift toward embracing health rather than embracing modern technology and cheap restaurants from the policy-makers to the schools and work places. Rewards for children, families, individual and corporations that meet criteria for being healthy could be a start....

Hi Sikandar,

have you ever heard something about thrifty genes? those genes will met the facts listed by Samantha and Joan, changes in lifestyles will create obesity and insulin resistance, leading to T2D.

some points on thrifty genes: https://en.wikipedia.org/wiki/Thrifty_gene_hypothesis

fred

Dear Frederic Lepretre

i guess this is the actual trigger "Thrifty gene" which adds more cardiovascular risk to subcontinental population. The initial predisposition probably is supplanted by the obesogenic lifestyles and related environmental triggers. But sometimes not all get the same same dose so genetic predispositions are the answer to this. thanks for the link you shared.

Still i feel there is more to add to this subject and much remain behind the curtains. Why few lean, active and with no prior family history suffer?

Grateful

genetics is more and more implicated in lot of disease.

but still, in metabolic disorders (diabetes, obesity and of course cardiovascular disorders), the problem is to analyse the consumption in regards to all spent. physical activities have a key role in the onset with a strong genetic background.

fred

The risk factors peculiar for developing diabetes

include high familial aggregation, central obesity, insulin resistance and life style changes due to urbanization. Screening for

gestational diabetes and impaired glucose tolerance among pregnant women provides a scope for primary prevention of the

disease in mothers as well as in their children.

Yes Entedhar Sarhat

You pointed out well. Gestational diabetes mellitus also predisposes to future risk of metabolic diseases including type-2 diabetes mellitus along genetic predisposition which is way higher for type-2 diabetes mellitus.

Bur still finding lean, physically fit and energetic people ending up in their thirties ending with metabolic complications including diabetes, which is worrisome.

Does our diets or environmental pollution could be a cause???????

Anyway thank you

عوامل كثيرة مسببة لهذا المرض منها واهمها نوع الطعام

Some hormonal diseases cause the body to produce too much of certain hormones, which sometimes cause insulin resistance and diabetes. Cushing's syndrome occurs when the body produces too much cortisol—often called the “stress hormone.” Type 2 diabetes has several causes: genetics and lifestyle are the most important ones. A combination of these factors can cause insulin resistance, when your body doesn't use insulin as well as it should. Insulin resistance is the most common cause of type 2 diabetes. Type 2 diabetes can be hereditary.

The chances of developing type 2 diabetes depend on a combination of risk factors such as your genes and lifestyle. Although you can't change risk factors such as family history, age, or ethnicity, you can change lifestyle risk factors around eating, physical activity, and weight. Diabetes is a chronic condition associated with abnormally high levels of sugar (glucose) in the blood. Insulin produced by the pancreas lowers blood glucose. Absence or insufficient production of insulin, or an inability of the body to properly use insulin causes diabetes.

Regards

PErsonally I think that trend has some relation with genetics. The people habituated with one kind of food habit for generations are having genetic status is to adjust that type. When anybody change it, s/he suffers from diseases like diabetes and high cholesterol related problems or obesity.

People of Indian subcontinent were accustomed for generations mainly with low calorie foods. Cereals like wheat, maize, jawar, rice and some pulses were the main food.

People of coastal and water lodging areas were habituated with fish and people of mainly dryer areas with milk and meat.

Meat was a food of some special occasion or festivals of a section of people. It was not available at plenty amount, I think it was the main reason.

Our body system (you may call it as genetics) are accustomed in such low calorie foods.

I think it is the main reason behind the problem.

Same type of reasons may be there in many countries.

NO original European of any cold country can live by eating the food of a poor villager of India, I think.

On reverse, no original Indian can be able to tolerate 3-4 kilograms of meat as food everyday like the meat eating people of cold Europe.

Thanks.

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