Why RelA has (p)ppGppase hydrolysis domain but no (p)ppGppase (hydrolysis) activity in E. coli?

30 January 2017 0 3K Report

Hi everyone! RelA/SpoT Homologue (RSH) proteins comprise a superfamily of enzymes that synthesize and/or hydrolyze the alarmone ppGpp, activator of the ‘‘stringent’’ response and regulator of cellular metabolism. Although RelA has not been found capable of ppGpp hydrolysis, it still carries an inactive hydrolysis domain. So, Why the RelA has (p)ppGppase hydrolysis domain but no (p)ppGppase (hydrolysis) activity in E. coli?

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