I did the experiment based on response surface method (central composite) in design expert software. At the end of the experiment, I had a quadratic regression model that it can used for predicting the response. also using optimizing section of design expert software, can be used for predicting. but there is a problem that I can't understand it: predicted value of response with equation that manually was done (it is 9) is not equal to predicting optimizing section of software (it is 12).why they are different? Also I check some articles and this issue exist in all of them.

thanks for guides.

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