take a look at this
https://www.news-medical.net/life-sciences/Limitations-of-Optical-Microscopy.aspx
Bhaskar,
All particles, whether matter or anti-matter have characteristic sizes that are many orders of magnitude smaller than the wavelength of light.
Consider the proton - a rather large object. It has an effective radius of about 10^-15 m.
Light has a wavelength of ~ 0.4 to 0.6^10-6 m.
So, a billion-fold difference.
As James Garry said, no elementary particles can be observed directly by any microscope of any kind. They are detected indirectly, observing the secondary effects they cause when passing through normal "condensed" matter. For example, when they are charged and have large energy, they ionize the material through which they are passing, leaving behind and ionized "trail" on which tiny drops or bubbles can coagulate, making the track visible when illuminated. When electric and magnetic fields are applied, we can see how the tracks get curved and we can derive many properties of the particles from such. The track detecting chambers are called cloud chambers and bubble chambers, respectively. See https://home.cern/news/news/experiments/how-make-your-own-cloud-chamber
(see https://en.wikipedia.org/wiki/Bubble_chamber). Other types of tell-tale devices are based on particle-induced scintillations and several other phenomena.
This said, to derive all we know about elementary particles took a lot of patient work, kind of a detective story based purely on indirect evidence - no direct observations, unfortunately.
take a look at this
https://www.news-medical.net/life-sciences/Limitations-of-Optical-Microscopy.aspx
No elementary particles can be observed directly by any microscope of any kind
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