Why olmesartan is not synthesized using enzymatic route???

More Narendra Uttamrao Mokashe's questions See All

How to purify gallic acid to get white crystals?

I have isolated gallic acid from triphala churna but it is light brown in colour.

11 January 2021 8,737 1 View

What is virtual photon field , how is it helpfull to explain the Lamb shift on hydrogen atom ?

It is known that the Lamb shift is the consequence of the interaction of the electron with its virtual photon field. What is the meaning of virtual photon field? And how is it helpful to explain...

03 December 2020 535 3 View

How to decide Courant number as solution progresses?

Hello, ##ANSYS, ##Fluent. I am using pressure based solver, implicit scheme, VOF method (solving steady state open channel flow), k-e-RNG, and Coupled algo. Initially, I assigned...

22 June 2020 3,591 21 View

How to preform coarse grained MD simulation in Gromacs?

Hello everyone, I want to perform coarse-grained MD simulations in Gromacs, this is the first time I am doing this. so, I need guidance regard Gromacs usage and how to perform coarse-grained MD...

24 November 2019 2,793 5 View

Can anybody help me in finding dataset of plant disease?

I am doing my phd work on plant disease identification using deep learning. So i am searching for data set of plant leaves of soybean and wheat please help me.

19 September 2019 9,653 6 View

Rapid Publication Journals in the Field of Wastewater and Environment Engineering ?

Please Suggest The SCI Journals with rapid publication in the field of wastewater and environmental engineering.

17 January 2019 2,594 6 View

How to add a graphical data in MATLAB simulink?

i have some part of the data from which i can plat the graph. for example in the mean time of calculation i need a particular value from the graph i can retrieve it. so how can i insert a graph in...

19 September 2018 2,399 1 View

How much minimum enrich ChIP DNA is required to proceed ChIP-seq?

26 April 2018 8,191 5 View

Why do elastomers swell more than other polymers during the extrusion?

I performed some experiments on ABS and EVA and observed more swelling in the case of EVA material during the extrusion. Can anyone explain why it is happening?

04 May 2017 1,403 1 View

Reference on Nitration of L-Phenylalanine

Nitration of L-Phenylalanine

17 March 2017 3,716 1 View

What is the most Operating System (OS) which can be INSTALL on Tiny hard devices like Raspberry Pi (RPi) hardware ?

I'm targeting to deploy a mesh network and manually configure MANET routing protocols. I'm preparing scenarios, architectures, and hard devices needed to do that. Are there some step-by-step...

03 March 2021 1,931 5 View

Ester cleavage conditions?

Hi all, I need to cleave the ester in Ethyl 2-amino-1H-imidazole-5-carboxylate to make the carboxylic acid and retrieve the product from solution to use in downstream applications of linking to...

01 March 2021 8,766 3 View

How can I integrate a routing protocol in a tiny device (e.g. Raspberry Pi)?

Hi Community, I'm facing the issue of integration/compiling a new routing protocol in a WSN simulator. The final goal is to successfully add, configure this routing protocol in hardware devices...

01 March 2021 9,332 6 View

Is it efficient to do liquid biopsy to investigate the gene expressions of the tumor?

To do liquid biopsy and look for specific gene expressions there are so many published papers. Thera are different protocols and procedures used to isolate circulating cell free RNA or mRNA from...

23 February 2021 7,326 5 View

How can I add a new WSN routing protocol in NS2 or NS3?

I'm trying to find in literature a way to help me adding a modified Yen's algorithm in ns2 or its variance ns3 or another simulator. Have you some tips which can be helpful, I'm opening in the...

19 February 2021 7,981 3 View

Any Homemade Organic Synthesis Practices?

Hi everyone, I am a teacher of Heterocycles Synthesis, Is there a home practice that you recommend for undergraduate students? A simulator would also be useful Due to the pandemic, students...

18 February 2021 2,769 4 View

How to predict the reaction pathway for electro organic synthesis?

Can anyone recommend some any software/models available that can predict substance reactivities and the reaction yield under a specific set of reaction conditions process and proposing pathways to...

17 February 2021 2,383 3 View

Has anyone encountered any problems with abm good microRNA primers for quantification of mature miRNAs?

I've been trying to quantitate mature microRNAs in 293T cells with and without 'X'. 2ug of total RNA (isolated by Trizol method) is converted to cDNA using All-in one microRNA cDNA synthesis kit...

17 February 2021 8,986 2 View

Possible reasons for high bioavailability after I.M and S.C. routes...?

What should be the possible reasons if we obtained more than 100% bioavailability of antibiotics (marbofloxacin) after I.M. and S.C. routes of administration in cattle species.

16 February 2021 971 4 View

How to measure acetic anhydride solution with 18M sulfuric acid?

I am doing research on the synthesis of paracetamol. I am preparing acetic anhydride solution with a few drops a sulfuric acid and wish to measure the pH of this solution. However my pH meter...

14 February 2021 8,699 3 View

Frank T. Edelmann

Hi Narendra Uttamrao Mokashe, below please find a link to a paper describing the enzymatic formation of olmesartan in human liver and intestine. Unfortunately I don't have access to the full text.

https://www.jbc.org/content/285/16/11892

S Kalaiselvan

Yes there are method which involve continuous production carboxymethylenebutenolidase homolog

Mikhail Nekrasov

It's cheaper to make chemically when logistics is working properly. It's a dirt-cheap generic, so doing extra research to make it biosynthetically was never really needed before. Now with strained logistics it can be a useful technology as it would not depend on energy and large production sites, hence would be useful for distributed low-scale producion.