I feel puzzled that HIV mainly infects immune cells because it needs CD4 as receptor and CCR5/CXCR4 as co-receptors for entry, but when some toxic genes are deleted and geome taken apart for vector use, it works efficiently in a wide range of cell types(for example, MCF-7 and HEK293FT).
Didier Poncet
for retroviral vector only the HIV "backbone" (+ gag and pol and tat proteins) is used because HIV can infect quiescent cells. The HIV envelope gene is replaced by the VSV envelope protein gene. as VSV use a ubiquitous receptor the chimeric particles can infect a lot of differnet cells
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