i'm not a toxicologist, but rather a clinical pharmacologist, but understood that ED50 as a concept is similar to LD50, including the steepness of the slope (and therefore, there could be relevance in the LD10-or LD90...
As Karel eluded to, the LD50 (or LC50) point on the toxicity curve is the most sensitive to change being on the steepest part of the curve. Also when ploting the variations around the curve, the variation is least around the mid-point, so it is the best point to compare one compound to another. The LD 0 or LD100 are not truly points that can be determined and are very insensitive when comparing one compound to another.
Correct. When plotted or calculated, the LC50 has the least variability of data compared to points near the outside like the LC90 or LC10. The LC50 has been used extensively by governments in regulatory work, but doesn't have much meaning to fish farmers. This is why my research includes the NOEC (No Observable Effect Concentration). See Straus et al 2018 - Toxicity of PAA to fish - variation among species and impact of water chemistry.
Good toxicity studies are more difficult to do than most people realize and many of them are done incorrectly or do not investigate the correct parameters. Good luck!!
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