Certainly no aspect of human biology in our current civilization stands in more need of scientific knowledge and courageous humility than that of sex. (Alan Gregg)
I would like to answer this important question, because I did interdisciplinary research on transgender topics for rather a long time (for instance: historical and systematic correlations between medical conceptions of hermaphroditism, travesty, and so-called 'transsexualism', on one hand, and their literary and cultural configurations, on the other, reaching from the 16th to the 20th century, cf. my book Biographische Operationen. Diskurse der Transsexualität, Munich 1996, 798 p.). In my opinion, the problem of discriminating persons involved in cultural (and other) types of investigations on the vast field of human sexuality (and gender difference) could be partially understood under psychologic or even psychanalytic aspects: For the 'ego' is not always rational (cf. the inherent limits of Enlightment traditions), or, as Sigmund Freud put it: 'The ego is not (the) master at home'. Since a long time, people tackling with sex-gender-subjects are often thought of being personally involved in those problems, in one way or another, for instance by presenting the so-called 'anomalies' themselves, which is definitely not the case. From a psychanalytic point of view, one might consider the multiple forms of discrimination they suffer - at least partly - as a result of unconscious projections, (dis-)identifications, defence mechanisms, etc. But one should not underestimate political interests and strategies behind the bulk of devaluating discourses (including 'hate speech'), for instance in the context of social media. It would be desirable to suggest more informed and differentiated debates doing justice to the inherent complexity of 'sex & gender' issues as a very central part of the human condition.
Thanks Runte for commenting, although this question has nothing to do with the transgender issue. Some people object strongly to the social stereotypes and customs associated with being male or female. But no one can change their sex. We are born male or female according to our reproductive anatomy. Intersex babies are rare and the only exception. Men and women are fundamentally different both sexually and emotionally. Dressing as the opposite sex and even having surgery cannot change this.
It is men, much more than women, who are aroused by identifying with the opposite sex. Most transvestites are heterosexual. Society, especially women, approach men with caution because of the male tendency for violence and aggression. Some men try to avoid this treatment by presenting themselves as women.
"It is well known that most sexual and violent crime is overwhelmingly committed by men and that’s why women and girls sometimes need their own safe space away from men. Not because all men pose a danger but because saying no to all men is a simple and effective way to keep women and girls safe." Nicola Williams https://fairplayforwomen.com/