When I tried lesioning through permanent ligation of common carotid arteries in rats bilaterally, most often I was presented with unilateral lesion effect. Can anyone explain why is this happening?
Thank you all in advance!
Dear Sathyamoorthy,
Rats have a strong system of collateral circulation, (Willis Circle), thus when the common carotid arteries are clamped bilaterally , the vertebrobasilar artery system could be enough to overcome the relative scarcity of oxygenated blood. But not always this system work efficiently.
The posterior communicating arteries from Willis circle are not always equal in diameter, this explain why sometimes a unilateral lesion is present.
I will attach one of our papers explaining the before mentioned fact.
Moreover, the CA1 neurons are the most vulnerable one to hypoxia.
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