Article on RG: Dementia paralytica (neurosyphilis): a clinical case study.

Nikola Ilankovic, Maja Ivkovic, Dragoclav Sokic, Andrej Ilankovic, Srdjan Milovanovic, Branislav Filipovic, Danijela Tiosavljevic, Vera Ilankovic, Veronika Bojic

The World Journal of Biological Psychiatry 08/2003; 4(3):135-8. · 3.57 Impact Factor

It is related to ApoE4.

http://www.newscientist.com/article/dn25412-genetic-risk-of-alzheimers-has-gender-bias.html

http://www.eurekalert.org/pub_releases/2012-06/sumc-arg060612.php

http://www.medindia.net/news/women-at-higher-risk-of-alzheimers-than-men-due-to-a-gene-variant-study-134718-1.htm

See also

http://www.eurekalert.org/pub_releases/2012-12/gi-gs120412.php

http://medicalxpress.com/news/2012-01-lifestyle-alzheimer-disease-related-brain-persons.html

http://www.eurekalert.org/pub_releases/2007-01/uorm-csv010307.php

Regards,

Joachim

Hormonal changes (i.e., estrogen) late in life have also been implicated:

http://www.sciencedirect.com/science/article/pii/S0018506X12001134

http://www.jmidlifehealth.org/article.asp?issn=0976-7800;year=2014;volume=5;issue=1;spage=38;epage=40;aulast=Jamshed

Yes. The hormonal change (low estrogens) diminish the protective effect of this hormons contra atherosclerosis. But the frequency of many infection is very, very high by some womens. Today by many mens, too, because promiscuity.

I am curious, what infection do we women suffer more of and how does promiscuity come into it? I know you go mad with syphilis but that is not Alzheimer's.... 

There are so many possible aspects to why women are more affected by Alzheimer's... women live longer, use deodorant for most of their lives (more aluminium) and take more medicines than men. In general as we age our stomach acid is lower therefore nutritional absorption is lower. Lower zinc, magnesium, selenium, iodine, omega oils etc combined with accumulated heavy metals, toxins and oxidants has to contribute to poorer cellular health and slowed repair. Infection lowers zinc and antioxidants so is this correlation or cause? 

This is an interesting question and one that could shed light on what is causing Alzheimer's dementia. There is growing evidence that ionizing radiation causes Alzheimer's, as found in the following papers:

1) Rodgers CC. Dental X-ray exposure and Alzheimer’s disease: a potential etiological association. Med Hypotheses. 2011 Jul;77(1):29-34. Epub 2011 Mar 31.

2) Begum N, Wang B, Mori M, Vares G. Does ionizing radiation influence Alzheimer’s disease risk? J Radiat Res. 2012 Nov;53(6):815-22. Epub 2012 Aug 7.

3) Kempf SJ, Azimzadeh O, Atkinson MJ, Tapio S. Long-term effects of ionising radiation on the brain: cause for concern? Radiat Environ Biophys. 2013 Mar;52(1):5-16. Epub 2012 Oct 26.

4) Cherry JD, Liu B, Frost JL, Lemere CA, Williams JP, Olschowka JA, O’Banion MK. Galactic cosmic radiation leads to cognitive impairment and increased aβ plaque accumulation in a mouse model of Alzheimer’s disease. PLoS One. 2012 7(12):e53275. Epub 2012 Dec 31.

5) Il, Wang W, Welford S et al. Ionizing radiation causes increased tau phosphorylation in primary neurons. J Neurochem. 2014 May 26. Coi 10.1111/jnc. 12769.

If Alzheimer's is causing both brain plaques and dementia (possibly comorbidities), then the question remains, why are women more likely to suffer from it? There is more than one possible answer, with a few possibilities being: 1) women are subject to more dental radiation due to undertaking more frequent dental visits; 2) women are more radiosensitive, due to their smaller size; 3) women live longer, making it more likely that they will be subject of possible long-term effects of head exposure to ionizing radiation. Previous respondents have also mentioned genes and hormones.

Caroline, the radiation as one of causes of so called Alzheimers disease is interesting, but this type of cortical dementia is not one disease, has many causes and the diagnosis is not clinical, but pathohystological (post mortem). The radiation is very important and frequent cause of malignancy!

Certainly high doses of ionizing radiation are associated with malignancies, which is why lower doses have been considered "benign." The long-term effects of head exposure to ionizing radiation have not been properly studied. Of particular concern are repeated exposures -- as happens with regular dental check-ups or occupational exposure, such as that experienced by pilots or astronauts who are subjected to more cosmic radiation. Other occupations of potential concern are aircraft mechanics who work with ionizing radiation to test the structural integrity of planes, veterinarians who physically restrain animals during x-rays and heart surgeons who do not take the recommended precautions when doing procedures that use radioactive tracers.

reference: http://en.wikipedia.org/wiki/John_O%27Keefe_%28neuroscientist%29

Professor John O' Keefe who have win Nobel Price for cognitive neuroscience, born in 1939 in  New York and he is currently working in London is related with this theme of the question. His orientation is focused on hypothalamus. 

So, if this part of the brain is causing disorders for Alchajmer, then you can support your theory and get explanation for female pre - getting disorder. Mostly center of  emotions are located here so thats why think that female or masculine behavior are predicted.  So, this is a typical "face mask" or "black whole" in the all researching s. Dont rush with conclusions.

R.

Dear Virginia, I agree with You, but the original "AD" was in group of PRESENILE dementias! Augusta D. was 56 years old and suffered from atypical psychosis with delusions, hallucination and secondary cognitive decline...The discovery from beta amiloids plaque in her brain from Nissl, was pathohzstological postmortem! Augusta D. died from sepsis! Today most of syndromas of dementias (presenile, senile, vascular, degenerative, ect.) are in one mixed group called "AD", without real ethiological approach...!? And the statistic (pushed from pharmaindustry) is unrealistic.

Hi Virginia,

The changing cohort idea for LOAD gender differences is interesting!  Never quite looked at it that way. The age-related artifact is also interesting, since the male longevity deficit has generally been falling in developed countries in recent years and (presumably) should continue to go down as gender differences in occupational stress levels equilibrate.

BTW, I've kept an eye on estrogens as AD risk factors for a while now (mainly for my university neurodegeneration course), and I must say that estrogens seem to be singularly difficult to pin down as an AD  risk factor, especially at the cellular level. 

is this a hypothesis? Are there really studies showing this with significant statistical evidence. Of course correlation to the age and confirmed disease state must be considered. I did not know if this is really done. But just to share my thoughts.... more women are available in this older age population  and the life expectation is also higher for them.... and considering that age is the highest risk factor and alzheimer is hypothized to be a "normal cell death related process" .... this could be a factor.

But originally the so called Alzheimers Disease and the Pick disease were PRESENIL dementias...

Later we had SDAT typus I and typus II (presenili and senil type)...

Both are postmortem, pathohystologcal dignoses, not clinical!

Augusta D. was 53  and has an atypical pszchosis with seconadry cognitive decline.. Sche died because SEPSIS!

Dear Marisol, why you and many others collegues have a total neglect for real causes of illnesses and of dementia syndroms, too? (ethiology) I mean - infection, physical and chemical causes. If we now the ethilogy or part of ethiology, we can work with targeted therapy, not only with symptomatic. For genetic disposition, we have no therapy! I can have all the genetis disposition for alcohol ar drug abuse, but I take not alcohol and drugs!

I agree with You in some thesis. The genetic predisposition without exposition to real causes is nothing. With all genetic and immunological predisposition for ebola nobody will get ebola without contact with ebola viruses and direct contact with people who are infected with ebola. Maybe if You read my article about Dementio paralitica (Neurolues), you can better understand the causal medicine.

In my opinion, the main reason if that pseudodemential depression is often mistaken for Altzheimer and because depression is more frequent among women.

It is of Paramount importance not to mistake any dementia (ou pseudo-) as Altzheimer, especially if curable !

I agree with Bernard Maroy!

Dear Nikola

If you are interrested in underrecognized features of depresion, I suggest you to  read my book or its english abstract

Ok. Thank You!

I agrre with once part of Your comment. Where can I see Your table with 27 risk factors? I think the old age is the biggest ris factor to life, too... 

In my opinion the AD is more common in females more than males is that due to genetic aspects and gene expression. Also egeneti cfactor is involved. One missing is the deficiency of vitamin d. Not only that less women expose their skin to sun light. Hormonal differences play an important role too. It is not one to one answer, it is very complex phenomenon. It's mechanism always related to ↑ Microbiota

 and ↑Inflammation with a reduction of Hepcidin hormonal secretion.

I agree with You dera Ashem. But the chronic infections/inflammation  are very, very important!

Chronic Lyme disease could be one of etiological factor by cortical dementia syndromas! It is Spirohetosis, too (as Lues, Syphilis) and simmilar in manifestations and folow up with Syphilis (Lues) and in final stadium with Neurolues (MID and Dementia paralytica).