Neuromuscular complications have been reported with GVHD with a frequency about 8%. Most common complication is myopathy/myositis. Others include neuropathy and NMJ disorders.

Animal models suggest that CNS GVHD is possible. However, this diagnosis is extremely difficult to secure in humans as a) it requires brain biopsy, b) biopsy must sufficiently discriminate from post transplant lymphoproliferative disorders, and c) many patients are extremely ill and unfortunately die before a diagnosis is secured. Also, presentations are heterogenous and there is no consensus on definition or diagnosis of CNS GVHD.

• Ruggiu, M., Cuccuini, W., Mokhtari, K., Meignin, V., Peffault de Latour, R., Robin, M., Fontbrune, F. S., Xhaard, A., Socié, G., & Michonneau, D. (2017). Case report: Central nervous system involvement of human graft versus host disease: Report of 7 cases and a review of literature. Medicine, 96(42), e8303. https://doi.org/10.1097/MD.0000000000008303
• New-Tolley, J., Smith, C., Koszyca, B., Otto, S., Maundrell, A., Bardy, P., Hiwase, D., Yong, A., Lewis, I., & Limaye, V. (2018). Inflammatory myopathies after allogeneic stem cell transplantation. Muscle & nerve, 58(6), 790–795. https://doi.org/10.1002/mus.26341