XRD peaks of drug in drug-loaded nano-particles are not shown. Do you know why?
Dear then must occur structural changes in your loaded drug, or may their amount will very less and their peak will not appeared.
You can also check it from the TEM & HR-TEM also
Adsorbed/loaded drugs are not detected by XRD due to the
very poor relative abundance/concentration than the carrier materials
almost amorphous in nature. In XRD,
sample scanning rate, reference materials and
other parameters are also very important to generate a peak of the corresponding materials.
Anish Hiresha Verma , first, as Muhammad Ismail has asked, is the loaded drug crystalline? If not, you should see an amorphous (broad) peak at lower angles of 2(theta). Also, if you are able to grow a single crystal of your drug, you should be able to pull out its powder pattern from the analyzed single crystal data.
My choice of drugs are crystalline in nature. And thank you so much for the inputs.
Dear then must occur structural changes in your loaded drug, or may their amount will very less and their peak will not appeared.
You can also check it from the TEM & HR-TEM also
Interesting question but i don't think so it happens in all the cases.
In XRD analysis, we have to mention that intensities of the structure is vital. After that, you said that your drugs material are crystalline, so in my opinion is your drugs concentration is far too small or is not successfully loaded into your nano-particles. Please justify this by doing a SEM-EDX analysis.
Is your drug is giving any peak when it's not loaded with nanoparticles, may be peak of nanoparticle is quite dominant and your drug peak is too small to visualize. So try doing XRD of drug without nanoparticles.
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