Ferrocene (Fc) has been regarded as a helpful catalyst for the electro-oxidation of dopamine, ascorbic acid, Levodopa, etc., at different potentials.
If anyone suggests to me any literature about why ferrocene works as a catalyst for particular analogs (e.g., dopamine, ascorbic acid, uric acid), not for others (e.g., glucose), that will be helpful.
Thanks.
Hello Sanjida,
thank you for sharing this very interestig technical question on RG. Ferrocene is highly popular as catalyst for electrooxidation reactions because it is redox-active itself. It can be easily oxidized to the dark blue ferrocenium (or ferricinium) cation Fc+ which can in turn be reduced back to ferrocene. Ferrocenium salts are excellent one-electron oxidation agents. The electroctalytic oxidation of ascorbic acid using ferrocene-modified platinum electrodes has already been reported in the late 1980's:
Article Electrocatalytic oxidation of ascorbic acid and voltammetric...
For some very interesting reading about the history of ferrocene and ferrocenium plase have a look at the following Open Access article:
The ferrocenium/ferrocene couple: a versatile redox switch
Article The ferrocenium/ferrocene couple: a versatile redox switch
Although glucose belongs to the group of reducing sugars, the oxidation potential of ferrocenium is not high enough to achieve oxidation of this molecule. In contrast, ascorbic acid is a well-known and often used reducing agent (e.g. for making Au nanoparticles), which means that it is itself easily oxidized.
Good luck with your research work and best wishes, Frank Edelmann
Hi. I hope the following article could help you: https://hal.archives-ouvertes.fr/hal-03066386/document
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