Why does antimycin A inhibits the development of paclitaxel-induced mechanical hypersensitivity?

25 January 2017 1 3K Report

Im having trouble understanding this paper: https://www.ncbi.nlm.nih.gov/pubmed/26142652

Title of the paper is Pharmacological Modulation of the Mitochondrial Electron Transport Chain in Paclitaxel-Induced Painful Peripheral Neuropathy

Why did she choose an inhibitor for a mitochondria disfunction. Im thinking about competive binding, because only before and during the administration the desired effect took place. But in the paper they never talked about competive binding. So can someone please give me more insights about this subject.

Astrit Gashi

http://www.jpain.org/article/S1526-5900(15)00723-3/abstract

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