As immunologist, I think the immune response against sugars "foreigners" is regulated as a classical immune response to others antigens. Maybe, in the development of the central tolerance, we can´t develop tolerance to this kind of carbohydrates due to their lack in our system. This is supported by the next fact: some humans are allergic to the laminin from B. taurus, a glycosylated protein in the animal, but no in humans (although the human has the gene but is off) . So, the IgE antibodies produced by the allergic persons can to recognize the carbohydrate determinant but not the protein, despite it is highly homologous with humans. Perhaps, this phenomen is similar to the carbohydrate determinants in protein from vegetals.

Marlon, atleast 50% of the proteins are glycosylated. I am finding antibodies binding to mannose, fucose, GalNAc and GlcNAc, which are commonly found on all the proteins.

Hi.

Perhaps own antibodies sugars due to a break in the peripheral tolerance. Autoimmunity such has not been previously described. What about your patients who suffer you extracted the antibodies a pathology ?.

the patient population has T1D, but the glycan antibodies are present in cancer patients sserum as well.

Hi there.

This is my theory on the origin of specific auto antibodies against carbohydrates.

If your patients have T1D, this may explain the origin of auto antibodies. On the other hand, the specificity toward carbohydrate antigens is determined by the Beta cells that are attacked by autoimmune processes. Therefore, when cells such as macrophages or dendritic cells capture antigens containing carbohydrates of the beta cells and presented to T and B lymphocytes, the latter produce autoantibodies against them.