It has been more than three decades since HIV/AIDS has already spread throughout all the five continents (North America, South America, Europe, Africa, Asia and Australia). A lot has been done to minimize the spread of the diseases. Different governmental and non-governmental organizations, civic societies and individuals have tried to create awareness about HIV at global, national and regional levels. Despite all those efforts, HIV/AIDS is still one of the major killer diseases, particularly in the developing regions.
Researchers have also worked day and night to discover and develop therapeutic and/or prophylactic agents against HIV/AIDS. For example, different research laboratories and companies have developed different vaccine candidates so far. Unfortunately, the vaccine candidates did not show promising protective efficacy during pre-clinical and clinical trials. Why?
Dear Alemu, these new reviews will help you , regards
Cold Spring Harb Perspect Biol. 2017 Jun 19. pii: a029389. doi: 10.1101/cshperspect.a029389. [Epub ahead of print]
What Are the Primary Limitations in B-Cell Affinity Maturation, and How Much Affinity Maturation Can We Drive with Vaccination? Lessons from the Antibody Response to HIV-1.
Victora GD1, Mouquet H2,3.
F1000Res. 2017 Apr 28;6:597. doi: 10.12688/f1000research.10876.1. eCollection 2017.
Recent advances in understanding HIV evolution.
Andrews SM1, Rowland-Jones S1.
Also suggest the following review:
Scully, Eileen, and Galit Alter. “NK Cells in HIV Disease.” Current HIV/AIDS Reports 13 (2016): 85–94. PMC. Web. 20 July 2017.
Hi,
HIV virus is known to produce mistakes during its process of multiplication. Mutations also occurs. So antigenic nature of this virus keeps on changing. That is a major hindrance in the development of effective vaccine. Live vaccine is always having the risk of new infection. Moreover, it is very difficult to remove the dormant virus exists in tissues and cells other than in the circulation. These are the few reasons because of which an effective vaccine trial is still in a stage of progress.
DR S.Murugan
Dear All,
Many thanks for your answers and for sharing the resources for further reading. I appreciate it.
In my opinion, I think this review provides a thorough insight on this topic.
https://www.ncbi.nlm.nih.gov/pubmed/28230655
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