can any explain some genetic differences responsible for EVR,RVR,SVR and NVR
There are multiple reasons which can be summarised as under :
[a] Stage of liver cirrhosis - those with more advanced disease responds poorly.
[b] IL 28B typing - those with TT genotype fares poorer compared to CC type.
[c] Adherence to treatment - Those needing temporary drug withdrawal or dose modification due to adverse events have poorer outcome. 80% of total dose and 80% of total duration has been found to be effective. Ribavirin dose is more important.
[d] Some other factors which might have genetic basis are that males, presence of NAFLD and other chronic liver disease and coinfection with other hepatotropic viruses have poorer outcome.
There are specific host genetic elements which are responsible for differential response.
Muhammad
I would say there is not two persons with the same genotype. Perhaps they have the same genotype for the loci you genotyped, but surely they differ at many loci and some of them could be of interest for responding to such combination of medicines.
Pablo
The response in HCV patients with chronic C hepatitis is influenced by other clinical factors, like age upper of 40 years, Child-Pough status, coinfected with HIV, sex (male present worse response rates), insulino-resistence status, previous relapse). You should take care and to evaluate these factors to adapting the therapy term.
There are multiple reasons which can be summarised as under :
[a] Stage of liver cirrhosis - those with more advanced disease responds poorly.
[b] IL 28B typing - those with TT genotype fares poorer compared to CC type.
[c] Adherence to treatment - Those needing temporary drug withdrawal or dose modification due to adverse events have poorer outcome. 80% of total dose and 80% of total duration has been found to be effective. Ribavirin dose is more important.
[d] Some other factors which might have genetic basis are that males, presence of NAFLD and other chronic liver disease and coinfection with other hepatotropic viruses have poorer outcome.
it depend on different reasons and one of them is the liver cirrhosis either its in first stage or in the late stages
Host genetic factors: i.e. Interleukin-12 (IL-12) p40 gene A1188C 3'UTR polymorphism seems to be involved to some extent in the success of the treatment.
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