on a micron and sub-micron structures made of silicon oxide and metal (no topographical features/aspect ratio is very small) why cells tend to adhere to the metal not oxide
This is not always the case. Sometimes silicon oxide do promote cell adhesion through a protein film attached to the surface. So I think that in your case, this has to do with silicon oxide termination. You could check the hydrophobicity of the silicon oxide (by contact angle measurements) and change it by functionalization (silanization) or plasma treatment. This will affect cell adhesion.
Hi Vincent, we observed cells adhering on silicon oxide as a result of protein layer adsorped on silicon/tungsten non-topographical surfaces using a culture medium containing FBS. do you have a credible source I can look at for silicon oxide promoting cell adhesion? what about the impact of Calcium in culture media and saline solution?
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