The electron density around Nitrogen may be a reason.  When it is surrounded by hydrocarbons, the electron density is further increases.  That may be a reason for tuning its properties by substitution.

Dear Abadi

Thank you for the answer.  Can you explain the mechanism nitrogen action over the enzymes.

Nitrogen compounds provide fertility to soil and thus enhanced bumper harvest.

The nitrogen is essential because N-compounds are used in formation of proteins in cells