It is such a trivial question. Mycoplsma has an Intrinsic Resistance to B-lactams since they lack the target (cell wall, peptidoglycan) on which the antibiotic can acts.
Like everyone has said, mycoplasmas have no rigid cell wall and can take up different shapes. Therefore there is no target to aim for by cell-wall lysing/inhibiting antibiotics.
Mycoplasma does not have cell wall and can not be killed with Penicillin and Cephallosporin derivative antibiotics that target cell wall synthesizing enzyme.
It is such a trivial question. Mycoplsma has an Intrinsic Resistance to B-lactams since they lack the target (cell wall, peptidoglycan) on which the antibiotic can acts.