Error Codes 100 - 199 indicate issues in amplicon capture primer designs; higher value error codes are avoidable by adjusting the amplicon length design settings.

From the online manual, this is  the result of a validation step takes actual

multiplexed assay designs and considers combinations of primers for both the assays as defined and in every other combination. The example given is  a 10-plex assay design represents 10 individual assays (uniplexes) that are to be run in the same reaction space but actually consists of 20 PCR primers and 10 extend primers. This

represents 200 PCR primer couplings that could result in amplification products. Any such amplicons produced may contain a sub-sequence that is a potential hybridization site for any of the 10 extend primers.