Is it the barrier it makes and decreases the absorption of food?
or the toxin it produces?
or the decomposition of bile salts?
or the inhibition of trypsin and lipase?
or the change it obligates on the intestine and villi?
or ...
please share your ideas with me
The disruption of the intestinal epithelial barrier integrity by using PROTEINASES and LECTIN, and these are the major virulence factor in the form of immuno-dominant protein play a vital role in the pathogenicity of Giardia lamblia. As, the initiation of infection is triggered with the loss of intestinal epithelial barrier integrity.
Pathogenesis and virulence depend on the genotype of the Giardia strain and the immune and nutritional status of the host. To date, eight genetic assemblages (A to H) have been described. It is well established that isolates from assemblages A and B cause infection in humans . There is, however, more recent evidence that isolates from assemblage E are pathogenic for humans, as well. Since these strains can be found in humans as well as in animals, giardiasis can be regarded as a zoonosis . Especially, young children living in poor sanitary conditions are exposed to giardiasis which—in combination with malnutrition or immunosuppression (e.g., HIV)—can be fatal. Moreover, persistent infections in children may cause stunting.
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