Dear Dr. Ahmed, I would suggest you several publications from Corio's group; among them, I could cite:

(1) COSTA, J. C. S. ; Ando, R.A. ; SANT'ANA, A. C. ; CORIO, P. . Surface-Enhanced Raman Spectroscopy Studies of Organophosphorous Model Molecules and Pesticides. PCCP. Physical Chemistry Chemical Physics (Print), v. 14, p. 15645-15651, 2012.

(2) SANT'ANA, A. C. ; COSTA, J. C. S. ; TEMPERINI, M. L. A. ; CORIO, P. . Chemical Analysis of polycyclic Aromatic hydrocarbons by Surface-Enhanced Raman Spectroscopy. Talanta (Oxford), v. 70, p. 1011-1016, 2006.

(3) CORDEIRO, D. S. ; CORIO, P. . ELECTROCHEMICAL AND PHOTOCATALYTIC REACTIONS OF POLYCYCLIC AROMATIC HYDROCARBONS INVESTIGATED BY RAMAN SPECTROSCOPY. Journal of the Brazilian Chemical Society, v. 20, p. 80-87, 2009.

But you could probably find several other papers from this group that might suit better your need.

Dear Dr. Gustavo,

Can you please tell me if Raman spectroscopy or SERS can be used to probe antibody- antigen interaction.

I would be glad if you could throw some light on same..

Supriya

Dear Dr. Srinivasan,

SERS (and SERRS, surface-enhanced resonance Raman scattering) may certainly be used to probe antibody-antigen interaction. Most of times, it is necessary to bind a so-called Raman-reporter, a adsorbate that has a strong and well-known SERS spectrum, though.

For reviews on the subject, I would suggest you:

- Marc D. Porter, Robert J. Lipert, Lorraine M. Siperko, Gufeng Wang and

Radha Narayanan, "Chemical Society Reviews", 2008, 37, 1001-1011;

- X.-M. Qian and S. M. Nie, "Chemical Society Reviews", 2008, 37, 912-920; (both above are related to SERS-based bioassays)

- M. Fan, G. F. S. Andrade, A. G. Brolo, "Analytica Chimica Acta", 2011, 693, 7-25 (a review that deals with general aspects of SERS substrates and applications in analytical chemistry)

Dear Dr.Andrade,

Is it possible to probe antigen- antibody interaction label free through SERS