Lung cancer? Head and neck? Brain? Peadiatric cancer?

To respond to your question, I can send to you a few papers that i consider the most interesting in this field. You may ask to the Authors. I'm also working on radio-sensitization and I'm trying to find a law for reduced time-higher temperature treatment. That would be useful for mixing HIFU and RT, that is my idea for increase the RT effectiveness and reduce side effects.

The last paper (Law) may is intriguing: it's difficult to accept that the Arrenius activation energy for thermal enhancement of radio-dermatitis (1030 kJ/mole) is higher that the activation energy for necrosis (580 kJ/mole).

I hope you can read the attached files (maybe you have them already!)

Maybe the best paper.

Authors have a long record of top level paper on Hyperthermia

Maybe the best center.

Personally, I like the papers of Horsman and Overgaard. But I am studying more the hyperthermia range from 40-44 degC. This is shown to be the optimum range for radiotherapy stimulation in animals. Hence, I expect that the optimum temperature in humans is only slightly shifter to higher temperatures. Further, radiotherapy stimulation is usually needed for larger tumors (that are eg hypoxic) and hence I am at treatment of targets of 5-15cm in length. As I understand now, HIFU might not be the best choice for this.

Different HIFU systems have different technical characteristics, so that the time required for treating a tumor may me heavily different. My statement refers to the system we used several years ago. Now the progress in the technology may have substantially reduced the treatment time. In addition, for the largest tumors, HIFU can be, eventually, administered in two or more session on overlapping regions to cover the whole diseased tissue. That may not feasible with RT, due to the dose limits in the surrounding structures where radiations doses add up and may reach a total value higher than clinically acceptable. In addition, tumors' regions already treated by HIFU need not to be treated again with radiations. In principle that would totally change the spatial distribution of concurrent RT, that can be restricted to a the relatively thin region where the tumor infiltrate the healthy tissue. But all that are speculations that should be compared with experimental data! I think that if you are interested in a deeper and more appropriate discussion I need to know better what kind of experiment you are planning. My best wishes,

Gianni