Which risk of bias tool should I use for a systematic literature review that contains mostly non-interventional studies?

22 March 2022 1 6K Report

Hi all,

I'm currently in the full text review phase of an SLR on predictors / risk factors of treatment resistant depression. I'm including observational studies and RCTs. Virtually all of these studies are non-interventional. For data synthesis, I'm looking to conduct a narrative summary of results, separated in categories such as clinical, genetic, demographic etc. I'm finding it quite difficult to source a risk of bias tool for non-interventional studies with the end product being a narrative summary. Does anyone have any suggestions regarding suitable RoB tools?

Thanks in advance!

Reza Mortazavi

Hi Shane,

For non-interventional studies, I would suggest the Newcastle-Ottawa Scale (NOS) instead of ROB tools because as far as I know ROB tools are mostly used for interventional studies (randomised and non-randomised). This is a link to the Newcastle-Ottawa Scale (NOS): http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp.

For interventional studies, I would use ROB tools. I hope this is useful.

Regards,

Reza

Badges
Science topic

Similar topics
Social Science
Media
Journalism

More Shane O'Connor's questions See All

How can sea water be used as an input for green hydrogen production?

If you extract sea water, and filter it, would it be suitable as an input for green hydrogen production? From an electrochemical perspective, would this be the only process step required?

13 December 2020 2,665 8 View

How to report a post-hoc comparison for robust mixed ANOVA?

Hi all I have conducted a robust mixed design ANOVA using WRS2 in R. My data are time taken in seconds, and not normally distributed. I cannot remove outliers as the experiment is based around...

23 July 2020 6,766 4 View

One possible process for implementing environmental sustainability?

Can the process be named and list 3 phases of how it would be implemented

14 July 2020 6,249 11 View

How do I produce a collimated image "beam" in my optical system?

I am trying to design an optical system to produce stereo images of an object with a single camera. To do this, I am going to utilize three mirrors: a reflector at each stereo angle and a...

13 July 2020 1,532 4 View

Can the Bray-Curtis Dissimilarity Index show differences in relative abundances of particular species. If not, which analyses can?

Hi all, I have a dataset of fish surveys containing counts of 80 or so species seen at 11 different reefs over a several year period. I would like to compare the community composition between...

13 May 2020 9,976 12 View

Can someone translate this paragraph into plain English?

Hi all, I'm looking into observational studies to try and better characterize treatment-resistant depression. I'm having trouble deciphering the paragraph in bold below, having read it multiple...

19 February 2020 9,823 2 View

Predicting the Age of home buyers - model based method?

All, I have a data-set which contains information on both the type of property an individual(s) purchased, along with some information on the individuals themselves. However, I am missing age...

19 February 2020 5,728 3 View

Techniques for removing electrosprayed nanoparticles from collector plates?

Hi, I am electrospraying polysaccharide micro particles directly onto a flat aluminium collector/foil surface. I am now trying to find a way to effectively remove them from the plate for...

04 February 2020 365 3 View

What can you tell me about an E.coli strain named Lemo21 from NEB?

I am currently trying to express human tyrosinase in E.coli and as you know this enzyme being a membrane protein it comes with a fair share of difficulties relating to expression in BL21(DE3)....

03 October 2018 6,996 3 View

Does anyone know of a working antibody against Orexin-A/Hypocretin-1 for immunofluorescence in Brain & Spinal Cord?

Our working antibody (https://www.scbt.com/scbt/product/orexin-a-antibody-c-19) has been discontinued, and we are looking for a replacement. We have tried 3 other antibodies (see below) to...

14 January 2018 9,040 5 View

I got 02 moderator values defining Johnson-Neyman significance regions. Is it an error?

Hi everyone, I am conducting research for my Master's thesis. I am using PROCESS by Johnson-Neyman to analyze my Moderator model. I test the relationship between Public Service Motivation and...

03 March 2021 2,350 2 View

How to code open-ended questions in SPSS?

Hello all, In SPSS I am going to code 2 open-ended questions. I have already read all the answers and I made a list of the most important categories to which I can code the answers. This question...

02 March 2021 1,757 4 View

How to eliminate Steady state error from Reinforcement learning genetic algorithm code?

The following code (see 1st 2 images attached) is used to produce PID controller values that are designed to control the system (G). The code finds the PID controller values (noted as k) by using...

28 February 2021 6,560 14 View

How could I process data in RCT to include it in meta-analysis?

I'm in the process of doing a meta-analysis and have encountered some problems with the RCT data. One of my outcom is muscle strength. In one study, I have three different measurements of muscle...

25 February 2021 7,603 3 View

What are the patterns of human behavior that lead to COVID-19 infections?

Does data from contact tracing help in establishing patterns of behavior and social interactions that lead to infections? There are cases here in the Philippines where patients have no travel...

25 February 2021 9,002 13 View

How to increase solubility of Poly acrylic acid in Dioxane solvent?

I am working with Polyacrylic acid (100.000Da) and instead of water, I need to use another solvent (dioxane) to dissolve PAA. However, because of the high molecular weight, it's quite hard to...

25 February 2021 2,225 5 View

Satellite orbit estimation using Recurrent Neural Network - what should I use?

Hello, I am a master's student studying in Yonsei Univeristy, Korea. I am trying to estimate the state of satellite, using Neural Network. Below is a simple flow of my study. 1. Train (t0 ~ t1)...

23 February 2021 6,383 3 View

Any Differences in COVID-19 vaccines?

Are there any differences (outside of the clinical trials that led to their EUA) observed in the rate of infection among those who have received the Pfizer vs Moderna vaccine since the mass...

22 February 2021 9,727 6 View

How can I get the coding gene sequences of Hela and U2OS cell lines? Is mRNA sequence of Hsp90 alpha tissue specific??

I am looking for hsp90 mRNA sequence in Hela and U2OS cell lines, I have tried through ncbi but always the output is hsp90 in homo sapiens not in the specific cell line. Kindly, could any one...

22 February 2021 1,853 3 View

How to constrain genetic algorithm input u?

My real system (buck converter) can only take an input of 0 to 1 (duty ratio) and I need to constrain the system so the controller action keeps within this bounds. How can I do this? The code for...

22 February 2021 2,125 3 View