There are different polyols for fabrication of biodegradable scaffolds. What parameters are important for selection of a specific polyol? Which polyol is the best candidate for both in vitro and in vivo applications?
My interest in this subject was more than 30 years ago but there was interruption which did not allow me to continue. Depending on memory: as you know, aliphatic polyesters have biodegradability & they are made by a reaction of a diol with a dicarboxylic acid. If one makes poly(ethylene adipate) or poly(ethylene sebacate) or poly(butylene succinate), it is not difficult to add a polyol such as poly(ethylene glycol) among the reacting monomers. PEG is known for its hydrophilic nature (highest priority parameter) which allows biodegradability. Of course, a terpolymer or copolymer will result. One must be careful not to synthesize a very high molecular weight terpolymer since this will hinder biodegradability.
Dear Dr. Matar
Great thanks for your response. As you know, there are novel biodegradable polyesters for example PGS and POC however, they suffer from weak mechanical properties. Therefore, how we can find a method for balancing the mechanical and degradable properties of polyesters?
Best regards Dr. Daemi.
I think that since polyesters display relatively strong mechanical properties & the polyols offer hydrophilic degradable moities and since the process of step- growth copolymerization depends on the molar ratios of the comonomers, then one may carry out few copolymerizations with varying amounts of (acid-diol-polyol). The resulting products are tested for mechanical strength & biodegradability.
Mind you, this research takes time but it is worthy & may offer you great opportunities.
At my old age (my photo was when I was younger), I need tolerant students to proceed with similar research topics & they are rare these days!
Sincerely dear Dr. Matar
I believe that the Science has gained its progress with respect to the great efforts of honourable researchers like you. Surely, devoting time for the synthesis of novel polyesters with unique mechanical properties is worthwhile.
You should try newly developed polyester polyols based on lactic acid oligomers in combination with succinic acid and certain diols/triols
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