olfactory, sleep disorder, orthostatic hypotension, excessive saliva, constipation, vision problems, gastrointestinal problems
The opinions of scientists are contradictory with respect to the importance of non-motor symptoms in Parkinson's disease.
https://www.atrainceu.com/course-all/parkinsons-disease-moving-forward-143
Professor Kulchitsky, thank you for providing the citation and weblink modules. The modules are very informative and easy to scan with headings.
Jordi, I appreciate your response regarding RBD. This is the topic I am pursuing with my latest research. The articles will assist in justification. Thank you.
Hi Linda,
It is proven that neuro-degeneration is effected by aging primarily through circadian rhythm.
Good read: http://www.nature.com/nrn/journal/v13/n5/full/nrn3208.html
As a therapist, i discovered that in elderly sleep disturbances occure prior to olfactory signs, or earlier noticed.
Hope this helps.
Success!
Jelena
Jelena, yes this is helpful. Thank you. The concept of motor consolidation with sleep is intertwined nicely in this article as well as the suggestion of daytime sleepiness. These are 2 concepts that I am incorporating into my research project.
Welcome, only take additional read about daytime sleepiness as it can be the sign of some other diseases ( worth mention in discussion).
I'd try to dissect it like this: gastrointestinal trouble including constipation will remain non-specific general symptoms with a high prevalence in the general population. Idem for vision problems, depression, and orthostatic hypotension (given the amount of treated cardiac insufficiency and its complications. So the most clear-cut will likely be sleep disorder as olfactory disorder is rarely mentioned spontaneously. So I agree with Jordi.
1.REM-sleep-behaviour-disorder- there are interesting studies of the correlation with alpha synuklein in skin biopsies-
but only small group of all PD patients has this disorder.
2.olfactory dysfunction tested with a sniff stick set.
Thank you all. I am feeling more confident that I am researching the sleep behavior component.
Hellow! i think sleep REM disorder and hyposmia may be the most predictive!
In 2015, there was a very interesting study by Hu et al published in Neurology 84:888-894. They used the REM Sleep Behavior Questionnaire (RBDSQ) to interview 225 PD patients. They found that 30.7% had probable RBD. The RBD group had more severe PD and higher levels of alpha-synuclein in CSF and serum.
You can review Nonmotor symptoms in LRRK2 G2019S Associated Parkinson´s Disease. PLoS One 2014;9(10) Carles Gaig and cols.
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