Which NSAIDs interact with aspirin due to binding on the same binding site of COX-1?

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Isabel M Costa

"Coxibs interfere with the action of aspirin by binding tightly to one monomer of cyclooxygenase-1" according to this PNAS 2009 paper: http://www.pnas.org/content/early/2009/11/18/0909765106.full

And "The concomitant administration of ibuprofen (...) antagonizes the irreversible platelet inhibition induced by aspirin" according to this NEJM 2001 paper: http://www.nejm.org/doi/full/10.1056/NEJMoa003199

Anca Negreanu

thank you very much for your help!

would aceclofenac interact with aspirin? Hinz et al in this article http://www.ncbi.nlm.nih.gov/pubmed/12966366 says that acelofenac spares the COX-1.