By big I'm assuming you can't solve it to optimality in a feasible computing time, so I'd suggest you to try changing MIPEmphasis to CPX_MIPEMPHASIS_FEASIBILITY (http://www.ibm.com/support/knowledgecenter/SS9UKU_12.4.0/com.ibm.cplex.zos.help/Parameters/topics/MIPEmphasis.html). This way the MIP solver will focus on finding good solutions rather than trying to prove optimality.