I am using different network inference tools like GENIE3 and TIGRESS which give directionality but not the sign of interaction (activation/inhibition). Some tools like Inferelator give it if we have a time-course data. I would like to know if i can get the sign of interactions from non-time course data and what the tools/software available are.
Thanks Sudhakar for the reply. I have used ARACNE and the problem here is one need to have many replicates in order to get better predictions. In their Nature protocol paper, they itself recommends to start with 100 replicates which is not possible in my analysis. There are some tools like inferelator but you need time course data. I'm just searching for some tool/method/approach to get the directionality based on static gene expression data.
- Badges
- Science topic
- Similar topics
- Phytochemistry
- Extracts