Hi, I want to make nano fragments of PLGA nanofibers. I have seen a some publications regarding the fragmentation of PLLA by Aminolysis. I want make nano fragments of PLGA instead of PLLA. I have figured out only two ways Aminolysis or Hydrolysis via stirring or sonication. However I am not sure about these two methods, either these methods work or not. If anybody has experience regarding this kindly let me suggest which may be the most suitable. Thanks in advance
Dear Taufiq,
you can try hydrolysis but in controlled way to get the desired fragment of your nanofibers. The time of exposure to water or water+heat need to be optimized.
with regards
I don't know about PLGA, but for polysaccharides, acid hydrolysis leads to a very polydisperse product, with a large amount of monomer and other low DP products. Sonication for prolonged periods can give a more uniform, monodisperse product. If your polymer chains are long enough, any high-shear physical treatment may work, such as extrusion, high-pressure homogenization, etc.
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