I'd like to know if there's a cell line (mammalian preferentially, but not exclusively) to study asymmetric cell division. Thanks!
C. elegans is an excellent model for asymmetric cell division and is great for developmental studies. As for cell lines, however, I am not sure I can be of much help. It may be possible to study C. elegans embryos in cell culture, which could be helpful as many of their early embryonic cell divisions are asymmetric.
Thank you, Tabitha. I will consider C. Elegans, for sure. However, I'm looking for (in my idealistic world) a cell line that I can easily culture in a dish to do some basic and initial experiments to test something. I don't have any expertise on C. Elegans, so I think it'll be a long learning phase for a simple experiment that I don't know it may work, if you know what I mean... :) Let's see what I can find out there in the literature as well. Thanks again, CG.
Hello
Asymmetric divisions of Drosophila neuroblasts (NBs) , sensory organ precursor (SOP) and ovarian stem cells used as examples for the intrinsic and extrinsic mode of asymmetric cell division.
Good Luck
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788323/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497809/
http://www.embopress.org/content/early/2016/11/21/embr.201643021
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0076195
http://www.cell.com/cell/abstract/S0092-8674(08)00208-0?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867408002080%3Fshowall%3Dtrue&cc=y
I think you can use C. elegans is an excellent model for asymmetric cell division
Thank you Saleh and Baheeja for your answers! I'll start working on those papers and recommendations soon. Cheers. CG.
- Badges
- Science topic
- Similar topics
- Biological Science
- Molecular Cell Biology