It is probably due to the inherent cellular microenvironment of epidermis that it may be required to position keratinocytes with high spatial resolution onto the dermis region, which is hard to accomplish via extrusion-based cell-printing method and the main limitation with inkjet-based bioprinting is the mechanical properties that printed structures are vulnerable due to use of low viscosity bioink, which in turn impedes the creation fully functional 3D structure. So which is better inkjet-based or extrusion-based?
Hi Nayereh,
Bioinks are getting very popular for 3D printing of skin. human plasma as well as primary human fibroblasts and keratinocytes are used for bioprinting of the skin.
Please see this good, recent paper from professor Jorcano group
3D bioprinting of functional human skin: production and in vivo analysis
Hope it helps
Amin
It is obvious that each have their pros and cons, so your question need a systematic review and meta-analysis to answer certainly. But as we discussed it in our upcoming chapter -which gladly will upload to my account after publication-, for this issue application of spheroids are showing great future which is applicable through extrusion based bio-printing. As biomechanical strength of scaffolds for skin regeneration is not necessary comparing to load bearing areas hydrogels are quite enough for application, which are base of spheroids. Hope my answer may help you.
Our extrusion based bioprinting platform has multiple users that are applying the technology for skin bioprinting. Let me know if you would like to learn more about Allevi bioprinters!
Lifeink 200 is a type I collagen designed for extrusion based bioprinters (https://www.bioprintabm.com/lifeink-200) that can be printed with low PSI. It is pure collagen, which is great for printing skin models.
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